William is suffering from guilt; and now, a ghost from his past has begun to follow him around. Hello, Again is a thoughtful examination of a man's neuroses. William's unease at his current situation (he's having an affair with his best friend's fiance) becomes incarnate as a drunken sailor who haunts the apartment complex that William manages. Thus, William's unresolved guilt at an otherwise harmless childhood prank becomes emblematic of his current woes. Max Estes tale is subtly complex look at how the mind deals with issues we'd rather avoid.
Unfortunately, Estes' loose, cartoony artwork (while excellent in its own right) really works against the tone of his story. The light and breezy atmosphere is at odds with the weightier issues that Estes is exploring. And it makes it difficult to take the story seriously.